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Discovery and characterization of 2 novel subpopulations of aPS/PT antibodies in patients at high risk of thrombosis

7 Jun 2019

Abstract excerpt

Anti-phosphatidylserine/prothrombin (aPS/PT) antibodies are often detected in patients with antiphospholipid syndrome (APS), but how aPS/PT engage prothrombin at the molecular level remains unknown. Here, the antigenic determinants of immunoglobulin G aPS/PT were investigated in 24 triple-positive APS patients at high risk of thrombosis by using prothrombin mutants biochemically trapped in closed and open...

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PMID: 31175129
DOI: 10.1182/bloodadvances.2019030932

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