Article
The conformational basis of thrombosis.
Thrombosis and haemostasis - 1 Jul 2001
Carrell R W, Huntington J A, Mushunje A, Zhou A
Abstract excerpt
Antithrombin readily undergoes a spontaneous transition from its active five-stranded form to a six-stranded inactive latent form. The recognition of this change in plasma has been obscured by the immediate linkage of newly formed latent antithrombin to a molecule of active antithrombin to give a dimer with an electrophoretic mobility readily confused with that of native active antithrombin. A new micromethod now...
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