Article
Conformational Asn187Asp/Lys antithrombin variants and thrombosis. Clinical and biological features in 13 new heterozygotes.
Thrombosis and haemostasis - 1 Jan 2005
Picard Véronique, Bauters Anne, Khairy Mahnouch, Ochat Nadège, Jude Brigitte, Aiach Martine, Alhenc-Gelas Martine
Abstract excerpt
Antithrombin Rouen VI (N187D) is a rare conformational thermolabile variant. The unique symptomatic carrier reported in the literature developed 3 thrombotic events during pregnancy, in each case in a context of pyrexial infection. In fresh plasma, antithrombin activity and antigen level were normal but in vitro experiments demonstrated the presence of a thermolabile variant, suggesting that fever could be a...
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