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Article

K-Ras(V14I) -induced Noonan syndrome predisposes to tumour development in mice.

The Journal of pathology - 1 Jun 2016

Hernández-Porras Isabel, Schuhmacher Alberto J, Garcia-Medina Raquel, Jiménez Beatriz, Cañamero Marta, de Martino Alba, Guerra Carmen

Abstract excerpt

The Noonan syndrome (NS) is an autosomal dominant genetic disorder characterized by short stature, craniofacial dysmorphism, and congenital heart defects. A significant proportion of NS patients may also develop myeloproliferative disorders (MPDs), including juvenile myelomonocytic leukaemia (JMML). Surprisingly, scarce information is available in relation to other tumour types in these patients. We have...

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Source

Identifiers

PMID: 27174785
DOI: 10.1002/path.4719

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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