Article
The coiled-coil domain is the structural determinant for mammalian homologues of Drosophila Sina-mediated degradation of promyelocytic leukemia protein and other tripartite motif proteins by the proteasome.
The Journal of biological chemistry - 13 Feb 2004
Fanelli Mirco, Fantozzi Anna, De Luca Pasquale, Caprodossi Sara, Matsuzawa Shu-ichi, Lazar Mitchell A, Pelicci Pier Giuseppe, Minucci Saverio
Abstract excerpt
Mammalian homologues of Drosophila Seven in Absentia (SIAHs) target for proteasome-mediated degradation several factors involved in cell growth and tumorigenesis. Here we show that SIAH-1/2 binds and targets for proteasome-mediated degradation the putative tumor suppressor and tripartite motif (TRIM) family member PML, leading to the loss of its transcriptional co-activating properties and a reduction in the...
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