Article
Elucidation of the substrate binding site of Siah ubiquitin ligase.
Structure (London, England : 1993) - 1 Apr 2006
House Colin M, Hancock Nancy C, Möller Andreas, Cromer Brett A, Fedorov Victor, Bowtell David D L, Parker Michael W, Polekhina Galina
Abstract excerpt
The Siah family of RING proteins function as ubiquitin ligase components, contributing to the degradation of multiple targets involved in cell growth, differentiation, angiogenesis, oncogenesis, and inflammation. Previously, a binding motif (degron) was recognized in many of the Siah degradation targets, suggesting that Siah itself may facilitate substrate recognition. We report the crystal structure of the Siah...
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