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Article

Requirement of the coiled-coil domain of PML-RARalpha oncoprotein for localization, sumoylation, and inhibition of monocyte differentiation.

Biochemical and biophysical research communications - 13 May 2005

Kim Young-Eui, Kim Dong-Yeon, Lee Jang-Mi, Kim Seong-Tae, Han Tae-Hee, Ahn Jin-Hyun

Abstract excerpt

Homo-oligomerization via a coiled-coil (C-C) domain has been shown to be necessary for the promyelocytic leukemia (PML)-retinoic acid receptor-alpha (RARalpha) fusion protein to acquire oncogenic potential in acute promyelocytic leukemia. We show here that PML(DeltaC-C)-RARalpha, which contains a deletion in its C-C domain, is neither localized as characteristic microspeckles nor modified by small ubiquitin-like...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15809060
DOI: 10.1016/j.bbrc.2005.03.052

Genes

PML

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 9 closest

Requirement of the coiled-coil domain of PML-RARalpha oncoprotein for localization, sumoylation, and inhibition of monocyte differentiation.PMID 15809060Read ↗

The coiled-coil domain is the structural determinant for mammalian homologues of Drosophila Sina-mediated degradation of promyelocytic leukemia protein and other tripartite motif proteins by the proteasome.Semantic proximity Read ↗

A sumoylation site in PML/RARA is essential for leukemic transformation.Semantic proximity Read ↗

Mutations at proximal cysteine residues in PML impair ATO binding by destabilizing the RBCC domain.Semantic proximity Read ↗

Dimerization-induced corepressor binding and relaxed DNA-binding specificity are critical for PML/RARA-induced immortalization.Semantic proximity Read ↗

Cytoplasmic function of mutant promyelocytic leukemia (PML) and PML-retinoic acid receptor-alpha.Semantic proximity Read ↗

Ret finger protein is a normal component of PML nuclear bodies and interacts directly with PMLSemantic proximity Read ↗

The Retinoic acid receptor alpha (RARalpha) chimeric proteins PML-, PLZF-, NPM-, and NuMA-RARalpha have distinct intracellular localization patterns.Semantic proximity Read ↗

The DNA binding property of PML/RARA but not the integrity of PML nuclear bodies is indispensable for leukemic transformation.Semantic proximity Read ↗

Effects on differentiation by the promyelocytic leukemia PML/RARalpha protein depend on the fusion of the PML protein dimerization and RARalpha DNA binding domains.Semantic proximity Read ↗

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