Article
A common variant in the glutathione S transferase gene is associated with elevated markers of inflammation and lipid peroxidation in subjects with diabetes mellitus.
Atherosclerosis - 1 Feb 2006
Hayek Tony, Stephens Jeffrey W, Hubbart Christina S, Acharya Jayshree, Caslake Muriel J, Hawe Emma, Miller George J, Hurel Steven J, Humphries Steve E
Abstract excerpt
INTRODUCTION: Glutathione S transferases (GST) are enzymes responsible for the metabolism of numerous xenobiotics and play a major cellular antioxidant role. Our aim was firstly, to examine the association between the GST M1/GST mu-1 (GSTM1) and GST T1/GST theta-1 (GSTT1) gene variants with markers of oxidative stress and inflammation in diabetic patients, and secondly to examine the association and potential...
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