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Article

Glutathione S-transferase genotype as a susceptibility factor in smoking-related coronary heart disease.

Atherosclerosis - 1 Apr 2000

Li R, Boerwinkle E, Olshan A F, Chambless L E, Pankow J S, Tyroler H A, Bray M, Pittman G S, Bell D A, Heiss G

Abstract excerpt

Cancer studies suggest that the null polymorphisms of glutathione S-transferase M1 or T1 (GSTM1/GSTT1) may affect the ability to detoxify or activate chemicals in cigarette smoke. The potential modification of the association between smoking and coronary heart disease (CHD) by GSTM1 and GSTT1 has not been studied in humans. A case-cohort study was conducted to test the hypotheses that specific genotypes of GSTM1...

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Source

Identifiers

PMID: 10729397
DOI: 10.1016/s0021-9150(99)00483-9

Genes

GSTM1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Glutathione S-transferase genotype as a susceptibility factor in smoking-related coronary heart disease.PMID 10729397Read ↗

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Glutathione S-transferase gene polymorphism as a susceptibility factor in smoking-related coronary artery disease.Semantic proximity Read ↗

An updated analysis on the association of GSTM1 polymorphism and smoking exposure with the increased risk of coronary heart disease.Semantic proximity Read ↗

Glutathione S-transferase M1 polymorphism and coronary heart disease susceptibility: a meta-analysis involving 47,596 subjects.Semantic proximity Read ↗

Risk of atherosclerosis: interaction of smoking and glutathione S-transferase genes.Semantic proximity Read ↗

Genetic polymorphisms of glutathione S-transferase genes GSTM1, GSTT1 and risk of coronary heart disease.Semantic proximity Read ↗

Interactive effect of the glutathione S-transferase genes and cigarette smoking on occurrence and severity of coronary artery risk.Semantic proximity Read ↗

GSTT1 null genotype contributes to coronary heart disease risk: a meta-analysis.Semantic proximity Read ↗

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