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Article

Homozygous C677T mutation in the MTHFR gene as an independent risk factor for multiple small-artery occlusions.

Thrombosis research - 1 Jan 2003

Choi B O, Kim N K, Kim S H, Kang M S, Lee S, Ahn J Y, Kim O J, Kim S, Oh D

Abstract excerpt

INTRODUCTION: Hyperhomocysteinemia is an independent risk factor for cerebrovascular disease and the homozygous C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene can induce hyperhomocysteinemia. However, the association between this 677TT genotype and ischemic stroke still remains controversial. Therefore, we carried out this study to determine whether the MTHFR TT genotype is associated with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14644077
DOI: 10.1016/j.thromres.2003.08.022

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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