Article
Logistic regression models for polymorphic and antagonistic pleiotropic gene action on human aging and longevity.
Annals of human genetics - 1 Nov 2003
Tan Qihua, Bathum L, Christiansen L, De Benedictis G, Dahlgaard J, Frizner N, Vach W, Vaupel J W, Yashin A I, Christensen K, Kruse T A
Abstract excerpt
In this paper, we apply logistic regression models to measure genetic association with human survival for highly polymorphic and pleiotropic genes. By modelling genotype frequency as a function of age, we introduce a logistic regression model with polytomous responses to handle the polymorphic situation. Genotype and allele-based parameterization can be used to investigate the modes of gene action and to reduce...
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