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Article

A model for antagonistic pleiotropic gene action for mortality and advanced age.

American journal of human genetics - 1 Jun 1998

Toupance B, Godelle B, Gouyon P H, Schächter F

Abstract excerpt

Association or linkage studies involving control and long-lived populations provide information on genes that influence longevity. However, the relationship between allele-specific differences in survival and the genetic structure of aging cohorts remains unclear. We model a heterogeneous cohort comprising several genotypes differing in age-specific mortality. In its most general form, without any specific...

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Identifiers

PMID: 9585593
DOI: 10.1086/301865
PMCID: PMC1377144

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Source receipt: pubmed, retrieved 7 Sept 2026.

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