Article
A model for antagonistic pleiotropic gene action for mortality and advanced age.
American journal of human genetics - 1 Jun 1998
Toupance B, Godelle B, Gouyon P H, Schächter F
Abstract excerpt
Association or linkage studies involving control and long-lived populations provide information on genes that influence longevity. However, the relationship between allele-specific differences in survival and the genetic structure of aging cohorts remains unclear. We model a heterogeneous cohort...
Topics
- Aging
- Cohort Studies
- Female
- Genetic Heterogeneity
- Genotype
- Humans
- Life Tables
- Longevity
- Male
- Models, Genetic
- Mortality
- Peptidyl-Dipeptidase A
- Sex Ratio