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Article

Induction of protective immunity against Burkholderia pseudomallei using attenuated mutants with defects in the intracellular life cycle.

Transactions of the Royal Society of Tropical Medicine and Hygiene - 1 Dec 2008

Breitbach Katrin, Köhler Jens, Steinmetz Ivo

Abstract excerpt

Melioidosis is a severe infectious disease caused by the Gram-negative rod Burkholderia pseudomallei. There is currently no vaccine available. We recently generated and characterized several highly attenuated transposon mutants with defects in the intracellular life cycle of B. pseudomallei. In the present study we examined the protective effects of six of these mutants: four harbouring knockouts in genes...

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Identifiers

PMID: 19121696
DOI: 10.1016/S0035-9203(08)70022-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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