Article
Subunit-subunit interactions in trimeric arginase. Generation of active monomers by mutation of a single amino acid.
The Journal of biological chemistry - 27 Apr 2001
Lavulo L T, Sossong T M, Brigham-Burke M R, Doyle M L, Cox J D, Christianson D W, Ash D E
Abstract excerpt
The structure of the trimeric, manganese metalloenzyme, rat liver arginase, has been previously determined at 2.1-A resolution (Kanyo, Z. F., Scolnick, L. R., Ash, D. E., and Christianson, D. W., (1996) Nature 383, 554-557). A key feature of this structure is a novel S-shaped oligomerization motif at the carboxyl terminus of the protein that mediates approximately 54% of the intermonomer contacts. Arg-308,...
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