Article
Chromosome-wide distribution of haplotype blocks and the role of recombination hot spots.
Nature genetics - 1 Mar 2003
Phillips M S, Lawrence R, Sachidanandam R, Morris A P, Balding D J, Donaldson M A, Studebaker J F, Ankener W M, Alfisi S V, Kuo F-S, Camisa A L, Pazorov V, Scott K E, Carey B J, Faith J, Katari G, Bhatti H A, Cyr J M, Derohannessian V, Elosua C, Forman A M, Grecco N M, Hock C R, Kuebler J M, Lathrop J A, Mockler M A, Nachtman E P, Restine S L, Varde S A, Hozza M J, Gelfand C A, Broxholme J, Abecasis G R, Boyce-Jacino M T, Cardon L R
Abstract excerpt
Recent studies of human populations suggest that the genome consists of chromosome segments that are ancestrally conserved ('haplotype blocks'; refs. 1-3) and have discrete boundaries defined by recombination hot spots. Using publicly available genetic markers, we have constructed a first-generation haplotype map of chromosome 19. As expected for this marker density, approximately one-third of the chromosome is...
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