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Article

Nephrin promotes cell-cell adhesion through homophilic interactions.

The American journal of pathology - 1 Dec 2003

Khoshnoodi Jamshid, Sigmundsson Kristmundur, Ofverstedt Lars-Göran, Skoglund Ulf, Obrink Björn, Wartiovaara Jorma, Tryggvason Karl

Abstract excerpt

Nephrin is a type-1 transmembrane protein and a key component of the podocyte slit diaphragm, the ultimate glomerular plasma filter. Genetic and acquired diseases affecting expression or function of nephrin lead to severe proteinuria and distortion or absence of the slit diaphragm. Here, we showe...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 14633607
DOI: 10.1016/S0002-9440(10)63590-0
PMCID: PMC1892394

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-14633607-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Nephrin promotes cell-cell adhesion through homophilic interactions.PMID 14633607Read ↗

Revisiting nephrin signaling and its specialized effects on the uniquely adaptable podocyteSemantic proximity Read ↗

Interaction of Endogenous Nephrin and CD2-Associated Protein in Mouse Epithelial M-1 Cell LineSemantic proximity Read ↗

Nephrin binds to the COOH terminus of a large-conductance Ca<sup>2+</sup>-activated K<sup>+</sup> channel isoform and regulates its expression on the cell surfaceSemantic proximity Read ↗

Nephrin-signature molecule of the glomerular podocyte?Semantic proximity Read ↗

Homodimerization and Heterodimerization of the Glomerular Podocyte Proteins Nephrin and NEPH1Semantic proximity Read ↗

Nephrin is specifically located at the slit diaphragm of glomerular podocytes.Semantic proximity Read ↗

Nephrin Signaling Results in Integrin β1 ActivationSemantic proximity Read ↗

Nephrotic plasma alters slit diaphragm-dependent signaling and translocates nephrin, Podocin, and CD2 associated protein in cultured human podocytes.Semantic proximity Read ↗

Interaction with Podocin Facilitates Nephrin SignalingSemantic proximity Read ↗

Motor Protein Myo1c Is a Podocyte Protein That Facilitates the Transport of Slit Diaphragm Protein Neph1 to the Podocyte MembraneSemantic proximity Read ↗

Phosphorylation of nephrin triggers its internalization by raft-mediated endocytosis.Semantic proximity Read ↗

Nephrin strands contribute to a porous slit diaphragm scaffold as revealed by electron tomography.Semantic proximity Read ↗

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