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Article

Reconstructed beta-catenin/TCF4 signaling in yeast applicable to functional evaluation of APC mutations.

The American journal of pathology - 1 Dec 2003

Yamada Hidehisa, Furuuchi Keiji, Aoyama Tetsuya, Kataoka Akihiko, Hamada Jun-ichi, Tada Mitsuhiro, Okushiba Shunichi, Kondo Satoshi, Moriuchi Tetsuya, Katoh Hiroyuki

Abstract excerpt

In human genetics and molecular oncology, mutation research is necessary not only to identify mutations in nucleic acid sequences, but also to analyze the loss of function caused by mutant proteins. We reconstructed a protein-protein network system of human beta-catenin and TCF4, in Saccharomyces...

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Topics

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Share to beta Catenin
Share to Colorectal Neoplasms
Share to Cytoskeletal Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, APC

Share to Mutation, Missense

Share to TCF Transcription Factors

Share to Trans-Activators

Share to Transcription Factor 7-Like 2 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 14633595
DOI: 10.1016/s0002-9440(10)63578-x
PMCID: PMC1892379

Genes

TCF4
APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14633595-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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