Article
Antibody responses to Porphyromonas gingivalis infection in a murine abscess model--involvement of gingipains and responses to re-infection.
Journal of periodontal research - 1 Dec 2003
Yoneda Masahiro, Hirofuji Takao, Motooka Noriko, Anan Hisashi, Hamachi Takafumi, Miura Mayumi, Ishihara Yoshihisa, Maeda Katsumasa
Abstract excerpt
BACKGROUND: Porphyromonas gingivalis is one of the most important periodontopathogens. It produces cysteine proteinases named gingipains. We previously examined the effect of gingipains on abscess formation in a murine model. The rgpA rgpB double and kgp mutants induced smaller abscesses than the wild type. Moreover, the rgpA rgpB kgp triple (gingipain-null) mutant hardly showed lesion formation at all under the...
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