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Article

Kgp and RgpB, but Not RgpA, Are Important for <i>Porphyromonas gingivalis</i> Virulence in the Murine Periodontitis Model

13 Jan 2007

Abstract excerpt

The contributions of three proteinase genes (rgpA, rgpB, and kgp) to the virulence of Porphyromonas gingivalis W50 were investigated in the murine periodontitis model. Mice were orally inoculated with eight doses (1 x 10(10) cells per dose) of rgpA, rgpB, kgp, rgpA rgpB, or rgpA rgpB kgp isogenic mutants, and the level of alveolar bone loss, immune response induced, and number of bacterial cells per half maxilla...

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PMID: 17220315
DOI: 10.1128/iai.01627-06

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