Article
A Sialidase-Deficient Porphyromonas gingivalis Mutant Strain Induces Less Interleukin-1β and Tumor Necrosis Factor-α in Epi4 Cells Than W83 Strain Through Regulation of c-Jun N-Terminal Kinase Pathway.
Journal of periodontology - 1 Aug 2017
Li Chen, Yang Xue, Pan Yaping, Yu Ning, Xu Xiaoyu, Tong Tong, Tang Xiaolin, Zhang Dongmei, Liu Jingbo, Lin Li
Abstract excerpt
BACKGROUND: Porphyromonas gingivalis is one of the major periodontal pathogens. In a previous study, a mouse abscess model showed that sialidase deficiency of P. gingivalis weakened its virulence, but the mechanism behind this observation remains unknown. METHODS: A sialidase-deficient mutant strain (△PG0352) and a complemented strain (com△PG0352) were constructed. Epi4 cells were stimulated by wild-type strain...
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