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Article

Homocysteine-betaine interactions in a murine model of 5,10-methylenetetrahydrofolate reductase deficiency.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Mar 2003

Schwahn Bernd C, Chen Zhoutao, Laryea Maurice D, Wendel Udo, Lussier-Cacan Suzanne, Genest Jacques, Mar Mei-Heng, Zeisel Steven H, Castro Carmen, Garrow Timothy, Rozen Rima

Abstract excerpt

Hyperhomocysteinemia, a proposed risk factor for cardiovascular disease, is also observed in other common disorders. The most frequent genetic cause of hyperhomocysteinemia is a mutated methylenetetrahydrofolate reductase (MTHFR), predominantly when folate status is impaired. MTHFR synthesizes a major methyl donor for homocysteine remethylation to methionine. We administered the alternate choline-derived methyl...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12551843
DOI: 10.1096/fj.02-0456fje

Genes

MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Homocysteine-betaine interactions in a murine model of 5,10-methylenetetrahydrofolate reductase deficiency.PMID 12551843Read ↗

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