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Article

Radioprotective effect of amifostine on cells from cancer prone patients and healthy individuals studied by the G2 and PCC assays.

International journal of radiation biology - 1 Oct 2003

Manola K N, Terzoudi G I, Dardoufas C E, Malik S I, Pantelias G E

Abstract excerpt

PURPOSE: To investigate whether amifostine is effective at reducing the yield of chromatid breaks when present during G(2)-phase irradiation of human normal cells and cells from cancer prone patients, as well as to study the mechanisms underlying the radioprotective effect of amifostine. MATERIALS AND METHODS: G(2) chromosomal radiosensitivity in the presence or absence of amifostine was studied in healthy...

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PMID: 14630542
DOI: 10.1080/09553000310001610222

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ATM

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