Article
The shuttling protein Npl3 promotes translation termination accuracy in Saccharomyces cerevisiae.
Journal of molecular biology - 4 Dec 2009
Estrella Luis A, Wilkinson Miles F, González Carlos I
Abstract excerpt
Heterogeneous nuclear ribonucleoproteins are multifunctional proteins that bind to newly synthesized mRNAs in the nucleus and participate in many subsequent steps of gene expression. A well-studied Saccharomyces cerevisiae heterogeneous nuclear ribonucleoprotein that has several nuclear functions is Npl3p. Here, we provide evidence that Npl3p also has a cytoplasmic role: it functions in translation termination...
Topics
- Genes, Fungal
- Kinetics
- Models, Biological
- Multiprotein Complexes
- Mutation
- Nuclear Proteins
- Peptide Chain Termination, Translational
- Poly(A)-Binding Proteins
- Protein Serine-Threonine Kinases
- Protein-Arginine N-Methyltransferases
- RNA Helicases
- RNA, Fungal
- RNA, Messenger
- RNA-Binding Proteins