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Article

Switching on cytotoxicity by a single mutation at the heavy chain variable region of an anti-ganglioside antibody.

Molecular immunology - 1 Apr 2011

Fernández-Marrero Yuniel, Hernández Tays, Roque-Navarro Lourdes, Talavera Ariel, Moreno Ernesto, Griñán Tania, Vázquez Ana María, de Acosta Cristina Mateo, Pérez Rolando, López-Requena Alejandro

Abstract excerpt

Gangliosides are sialic acid-containing glycosphingolipids present in the plasma membrane of most mammalian cells. In humans, the expression of the N-glycolylated (Neu5Gc) variant of the sialic acid has been associated with malignant transformation, constituting therefore an attractive target for cancer immunotherapy. P3 monoclonal antibody (mAb) recognizes Neu5Gc-containing gangliosides, as well as sulfatides....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21306777
DOI: 10.1016/j.molimm.2011.01.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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