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Article

Metallothioneins regulate ATP7A trafficking and control cell viability during copper deficiency and excess.

Scientific reports - 12 May 2020

Gudekar Nikita, Shanbhag Vinit, Wang Yanfang, Ralle Martina, Weisman Gary A, Petris Michael J

Abstract excerpt

Copper (Cu) is an essential, yet potentially toxic nutrient, as illustrated by inherited diseases of copper deficiency and excess. Elevated expression of the ATP7A Cu exporter is known to confer copper tolerance, however, the contribution of metal-binding metallothioneins is less clear. In this study, we investigated the relative contributions of ATP7A and the metallothioneins MT-I and MT-II to cell viability...

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Identifiers

PMID: 32398691
DOI: 10.1038/s41598-020-64521-3
PMCID: PMC7217913

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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