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Article

Leptin receptor polymorphism is associated with serum lipid levels and impairment of cholesterol lowering effect by simvastatin in Japanese men.

Diabetes research and clinical practice - 1 Dec 2003

Takahashi-Yasuno Akiko, Masuzaki Hiroaki, Miyawaki Takashi, Ogawa Yoshihiro, Matsuoka Naoki, Hayashi Tatsuya, Hosoda Kiminori, Inoue Gen, Yoshimasa Yasunao, Nakao Kazuwa

Abstract excerpt

OBJECTIVE: To investigate whether leptin receptor (Ob-R) Arg223Gln polymorphism influences serum lipid levels and whether this polymorphism affects the efficiency of the cholesterol lowering HMG-CoA reductase inhibitor, simvastatin [Clin. Cardiol. 16 (1993) 317]. DESIGN: Case-control association study. SUBJECTS: We studied 201 Japanese men without medical care, and 78 Japanese who took simvastatin. METHODS:...

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PMID: 14625131
DOI: 10.1016/s0168-8227(03)00163-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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