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Article

The 223A>G polymorphism of the leptin receptor gene and lipid-lowering efficacy of simvastatin in Chinese patients with coronary heart disease.

European journal of clinical pharmacology - 1 Feb 2009

Sun Yan-Ming, Wang Lan-Feng, Li Jia, Li Zhu-Qin, Pan Wei

Abstract excerpt

OBJECTIVE: To investigate whether leptin receptor (LEPR) 223A>G polymorphism influences serum lipid levels and whether this polymorphism affects the effectiveness of simvastatin in Chinese patients with coronary heart disease (CHD). METHODS: A total of 312 patients with CHD were treated with simvastatin 20 mg/day. Fasting serum lipids were determined before and after 12 weeks of treatment. RESULTS: Patients with...

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Source

Identifiers

PMID: 18854995
DOI: 10.1007/s00228-008-0578-3

Genes

LEPR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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