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Article

The Gln223Arg polymorphism in the leptin receptor is associated with familial combined hyperlipidemia.

International journal of obesity (2005) - 1 Jun 2006

van der Vleuten G M, Kluijtmans L A, Hijmans A, Blom H J, Stalenhoef A F H, de Graaf J

Abstract excerpt

OBJECTIVE: Familial combined hyperlipidemia (FCH) is characterized by elevated levels of total cholesterol (TC), triglycerides (TG) and apolipoprotein B (apo B) and is associated with premature cardiovascular disease (CVD). Other features of FCH are obesity and insulin resistance. Serum leptin levels have also been associated with obesity, insulin resistance and atherosclerosis. Leptin exerts its effect through...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16432543
DOI: 10.1038/sj.ijo.0803234

Genes

LEPR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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