Article
A dominant negative allele of p34cdc2 shows altered phosphoamino acid content and sequesters p56cdc13 cyclin.
Molecular and cellular biology - 1 May 1992
Fleig U N, Gould K L, Nurse P
Abstract excerpt
The cdc2 gene product, a 34-kDa phosphoprotein with serine/threonine protein kinase activity, has been implicated as the key component in the regulation of the eucaryotic cell cycle. Activation of the cdc2 protein kinase is regulated by its phosphorylation state and by interaction with other prot...
Topics
- Alleles
- Amino Acid Sequence
- Amino Acids
- Animals
- CDC2 Protein Kinase
- Cyclins
- G2 Phase
- Genes, Dominant
- Genes, Fungal
- Genes, Lethal
- Humans
- Hydroxylamine
- Hydroxylamines
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Phosphorylation
- Restriction Mapping
- Schizosaccharomyces