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Article

Zap1 Regulates Zinc Homeostasis and Modulates Virulence in Cryptococcus gattii

20 Aug 2012

Abstract excerpt

Zinc homeostasis is essential for fungal growth, as this metal is a critical structural component of several proteins, including transcription factors. The fungal pathogen Cryptococcus gattii obtains zinc from the stringent zinc-limiting milieu of the host during the infection process. To characterize the zinc metabolism in C. gattii and its relationship to fungal virulence, the zinc finger protein Zap1 was...

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PMID: 22916306
DOI: 10.1371/journal.pone.0043773

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