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Article

Nitrogen metabolite repression of metabolism and virulence in the human fungal pathogen Cryptococcus neoformans.

Genetics - 1 Jun 2011

Lee I Russel, Chow Eve W L, Morrow Carl A, Djordjevic Julianne T, Fraser James A

Abstract excerpt

Proper regulation of metabolism is essential to maximizing fitness of organisms in their chosen environmental niche. Nitrogen metabolite repression is an example of a regulatory mechanism in fungi that enables preferential utilization of easily assimilated nitrogen sources, such as ammonium, to conserve resources. Here we provide genetic, transcriptional, and phenotypic evidence of nitrogen metabolite repression...

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Identifiers

PMID: 21441208
DOI: 10.1534/genetics.111.128538
PMCID: PMC3122321

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