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Article

Factor V I359T: a novel mutation associated with thrombosis and resistance to activated protein C.

British journal of haematology - 1 Nov 2003

Mumford A D, McVey J H, Morse C V, Gomez K, Steen M, Norstrom E A, Tuddenham E G D, Dahlback B, Bolton-Maggs P H B

Abstract excerpt

We report a kindred in which two siblings suffered spontaneous venous thromboses in the second decade of life. Further investigation showed reduced coagulation factor V (FV) activity and activated protein C resistance (APCR) ratio but no other thrombophilic abnormalities. The reduction in APCR ratio persisted in a modified APCR assay in which FV activity was normalized between test and control plasmas. Analysis...

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PMID: 14617013
DOI: 10.1046/j.1365-2141.2003.04624.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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