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Article

Misregulation of histone acetylation in Sertoli cell-only syndrome and testicular cancer

12 Nov 2003

Abstract excerpt

In many species, including humans, chromatin remodelling during spermiogenesis is initiated with a marked increase in histone acetylation in elongating spermatids. We have investigated whether this process is disturbed when spermatogenesis is defective or in human testicular tumours. For this purpose, the presence of highly acetylated histone H4 was detected on testicular sections from men with a severe...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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PMID: 14614037
DOI: 10.1093/molehr/gag101

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