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Epigenetics and testicular germ cell tumors

29 Mar 2018

Abstract excerpt

Malignant testicular germ cell tumors (TGCTs) are the most frequent testicular cancers in Caucasian males, developing at the most productive age of man. We are briefly reviewing TGCT-tumorigenesis with an emphasis on epigenetics. Epigenetic mechanisms such as DNA methylation and histone modifications together with RNA interference that all change gene expression are driving early spermatogenesis. Deregulation of...

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PMID: 29605605
DOI: 10.1016/j.gene.2018.03.072

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