Article
An experimental model to study the in vivo survival of von Willebrand factor. Basic aspects and application to the R1205H mutation.
The Journal of biological chemistry - 26 Mar 2004
Lenting Peter J, Westein Erik, Terraube Virginie, Ribba Anne-Sophie, Huizinga Eric G, Meyer Dominique, de Groot Philip G, Denis Cécile V
Abstract excerpt
To explore the molecular basis of von Willebrand factor (VWF) clearance, an experimental model employing VWF-deficient mice was developed. Biodistribution was examined by the injection of radiolabeled VWF, which was primarily directed to the liver with minor amounts in other organs. Disappearance of VWF from plasma was characterized by a rapid initial phase (t((1/2))alpha = 13 min) and a slow secondary phase...
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