Article
Variants of the KCNMB3 regulatory subunit of maxi BK channels affect channel inactivation.
Physiological genomics - 11 Nov 2003
Hu Song, Labuda Malgorzata Z, Pandolfo Massimo, Goss Greg G, McDermid Heather E, Ali Declan W
Abstract excerpt
The steady-state and kinetic properties of the KCNMB3 regulatory subunits associated with calcium-activated potassium channels (BK channels) are presented. BK channels containing four sequence variants (V1-V4) in the four different isoforms of the beta-subunit (beta3a, beta3b, beta3c, and beta3d) were expressed in Xenopus oocytes. Reconstituted BK channel inactivation ranged from none to around 90% inactivation....
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