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Article

C677T methylenetetrahydrofolate reductase polymorphism interferes with the effects of folic acid and zinc sulfate on sperm concentration.

Fertility and sterility - 1 Nov 2003

Ebisch Inge M W, van Heerde Waander L, Thomas Chris M G, van der Put Nathalie, Wong Wai Yee, Steegers-Theunissen Régine P M

Abstract excerpt

OBJECTIVE: To determine the frequency of C677T methylenetetrahydrofolate reductase (MTHFR) polymorphism in fertile and subfertile males, and the MTHFR-dependent response of sperm concentration after folic acid and/or zinc sulfate intervention. DESIGN: Double-blind, placebo-controlled intervention study. Two outpatient fertility clinics and nine midwifery practices in The Netherlands. PATIENT(S): One hundred...

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Source

Identifiers

PMID: 14607573
DOI: 10.1016/s0015-0282(03)02157-5

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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