Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of the MTHFR A1298C variant with unexplained severe male infertility.

PloS one - 1 Jan 2012

Eloualid Abdelmajid, Abidi Omar, Charif Majida, El Houate Brahim, Benrahma Houda, Louanjli Noureddine, Chadli Elbakkay, Ajjemami Maria, Barakat Abdelhamid, Bashamboo Anu, McElreavey Ken, Rhaissi Houria, Rouba Hassan

Abstract excerpt

The methylenetetrahydrofolate reductase (MTHFR) gene is one of the main regulatory enzymes involved in folate metabolism, DNA synthesis and remethylation reactions. The influence of MTHFR variants on male infertility is not completely understood. The objective of this study was to analyze the distribution of the MTHFR C677T and A1298C variants using PCR-Restriction Fragment Length Polymorphism (RFLP) in a case...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to DNA Primers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MTHFR gene

Share to Infertility, Male

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Polymerase Chain Reaction

Share to Polymorphism, Restriction Fragment Length

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 22457816
DOI: 10.1371/journal.pone.0034111
PMCID: PMC3311580

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of the MTHFR A1298C variant with unexplained severe male infertility.PMID 22457816Read ↗

Association of C677T transition of the human methylenetetrahydrofolate reductase (MTHFR) gene with male infertility.Semantic proximity Read ↗

Significant impact of the MTHFR polymorphisms and haplotypes on male infertility risk.Semantic proximity Read ↗

Association of the Methylenetetrahydrofolate Reductase Gene A1298C Polymorphism with Male Infertility: A Meta‐AnalysisSemantic proximity Read ↗

Association of the MTHFR 677C>T and 1298A>C polymorphisms and male infertility risk: a meta-analysis.Semantic proximity Read ↗

MTHFR A1298C polymorphism and idiopathic male infertility.Semantic proximity Read ↗

Association between MTHFR A1298C polymorphism and male infertility: A meta-analysis.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase polymorphisms are related to male infertility in Brazilian men.Semantic proximity Read ↗

Relationship between genetic polymorphisms of methylenetetrahydrofolate reductase (C677T, A1298C, and G1793A) as risk factors for idiopathic male infertility.Semantic proximity Read ↗

Association between C677T and A1298C polymorphisms of the MTHFR gene and risk of male infertility: a meta-analysis.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and male infertility risk: An updated meta-analysis.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase C677T polymorphism and the risk of male infertility: a meta‐analysisSemantic proximity Read ↗

MTHFR 677C>T and 1298A>C polymorphisms and male infertility risk: a meta-analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.