Homozygous Methylenetetrahydrofolate Reductase C677T Mutation and Male Infertility

Abstract excerpt

To the Editor: Methylenetetrahydrofolate reductase (MTHFR) catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. The C677T in the gene that encodes MTHFR decreases the activity of the enzyme by 35 percent in persons who are heterozygous for the mutation and by 70 percent in those who are homozygous.1 The prevalence of the homozygous form is estimated to be between 5 percent and 10...

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