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Frequency of Binary Toxin Genes among <i>Clostridium difficile</i> Strains That Do Not Produce Large Clostridial Toxins

1 Nov 2003

Abstract excerpt

Pathogenic strains of Clostridium difficile commonly produce two large clostridial toxins (LCTs), A and B, virulence factors responsible for C. difficile disease. Some strains have been reported to produce an additional toxin, a binary toxin designated CDT. Binary toxin has cytotoxic effects on cells in culture, but its role in human disease is not yet defined. In this study we examined the frequency of binary...

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PMID: 14605169
DOI: 10.1128/jcm.41.11.5227-5232.2003

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