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Binary Toxin–Producing, Large Clostridial Toxin–Negative<i>Clostridium difficile</i>Strains Are Enterotoxic but Do Not Cause Disease in Hamsters

5 Apr 2006

Abstract excerpt

Binary toxin CDT or its genes have been identified in some strains of Clostridium difficile that also produce the large clostridial toxins, toxins A and B (A+B+CDT+), including a newly recognized epidemic strain in the United States and Canada. To study the effects of binary toxin alone, we characterized 4 binary toxin CDT-positive only (A-B-CDT+) C. difficile strains. Unlike other clostridial binary toxins,...

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PMID: 16544255
DOI: 10.1086/501368

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