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Article

Structure of a complex between E. coli DNA topoisomerase I and single-stranded DNA.

Structure (London, England : 1993) - 1 Nov 2003

Perry Kay, Mondragón Alfonso

Abstract excerpt

In order to gain insights into the mechaism of ssDNA binding and recognition by Escherichia coli DNA topoisomerase I, the structure of the 67 kDa N-terminal fragment of topoisomerase I was solved in complex with ssDNA. The structure reveals a new conformational stage in the multistep catalytic cycle of type IA topoisomerases. In the structure, the ssDNA binding groove leading to the active site is occupied, but...

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Identifiers

PMID: 14604525
DOI: 10.1016/j.str.2003.09.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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