Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structural and Dynamical Effects Induced by the Anticancer Drug Topotecan on the Human Topoisomerase I – DNA Complex

3 Jun 2010

Abstract excerpt

BACKGROUND: Human topoisomerase I catalyzes the relaxation of DNA supercoils in fundamental cell processes like transcription, replication and chromosomal segregation. It is the only target of the camptothecin family of anticancer drugs. Among these, topotecan has been used to treat lung and ovarian carcinoma for several years. Camptothecins reversibly binds to the covalent intermediate DNA-enzyme, stabilizing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bioactive Compounds and Antitumor Agents
Share to Cancer therapeutics and mechanisms
Share to Lung Cancer Research Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20532182
DOI: 10.1371/journal.pone.0010934

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structural and Dynamical Effects Induced by the Anticancer Drug Topotecan on the Human Topoisomerase I – DNA ComplexPMID 20532182Read ↗

Thr729 in human topoisomerase I modulates anti-cancer drug resistance by altering protein domain communications as suggested by molecular dynamics simulations.Semantic proximity Read ↗

Mechanisms of camptothecin resistance by human topoisomerase I mutations.Semantic proximity Read ↗

The mechanism of topoisomerase I poisoning by a camptothecin analog.Semantic proximity Read ↗

Molecular principle of topotecan resistance by topoisomerase I mutations through molecular modeling approaches.Semantic proximity Read ↗

Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA.Semantic proximity Read ↗

Structural insight of DNA topoisomerases I from camptothecin-producing plants revealed by molecular dynamics simulations.Semantic proximity Read ↗

A structural model for the ternary cleavable complex formed between human topoisomerase I, DNA, and camptothecin.Semantic proximity Read ↗

Cryo-EM structural analysis of human TOP1 trapping by eight clinical anticancer drugsSemantic proximity Read ↗

Structural basis of type II topoisomerase inhibition by the anticancer drug etoposide.Semantic proximity Read ↗

Novel insights into catalytic mechanism from a crystal structure of human topoisomerase I in complex with DNA.Semantic proximity Read ↗

Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex.Semantic proximity Read ↗

Etoposide promotes DNA loop trapping and barrier formation by topoisomerase IISemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.