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Article

Conformational flexibility in T4 endonuclease VII revealed by crystallography: implications for substrate binding and cleavage.

Journal of molecular biology - 27 Apr 2001

Raaijmakers H, Törö I, Birkenbihl R, Kemper B, Suck D

Abstract excerpt

The structure of the N62D mutant of the junction-resolving endonuclease VII (EndoVII) from phage T4 has been refined at 1.3 A, and a second wild-type crystal form solved and refined at 2.8 A resolution. Comparison of the mutant with the wild-type protein structure in two different crystal environments reveals considerable conformational flexibility at the dimer level affecting the substrate-binding cleft, the...

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Identifiers

PMID: 11327769
DOI: 10.1006/jmbi.2001.4592

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