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Article

Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA.

Science (New York, N.Y.) - 6 Mar 1998

Redinbo M R, Stewart L, Kuhn P, Champoux J J, Hol W G

Abstract excerpt

Topoisomerases I promote the relaxation of DNA superhelical tension by introducing a transient single-stranded break in duplex DNA and are vital for the processes of replication, transcription, and recombination. The crystal structures at 2.1 and 2.5 angstrom resolution of reconstituted human topoisomerase I comprising the core and carboxyl-terminal domains in covalent and noncovalent complexes with 22-base pair...

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PMID: 9488644
DOI: 10.1126/science.279.5356.1504

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