Article
The high frequency Indian rhesus macaque MHC class I molecule, Mamu-B*01, does not appear to be involved in CD8+ T lymphocyte responses to SIVmac239.
Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2005
Loffredo John T, Sidney John, Piaskowski Shari, Szymanski Andrew, Furlott Jessica, Rudersdorf Richard, Reed Jason, Peters Bjoern, Hickman-Miller Heather D, Bardet Wilfried, Rehrauer William M, O'Connor David H, Wilson Nancy A, Hildebrand William H, Sette Alessandro, Watkins David I
Abstract excerpt
Although the SIV-infected Indian rhesus macaque (Macaca mulatta) is the animal model most widely used for studying HIV infection, our current understanding of the functional macaque MHC class I molecules is limited. To date, SIV-derived CD8+ T lymphocyte epitopes from only three high frequency macaque MHC class I molecules have been extensively characterized. In this study, we defined the peptide-binding...
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