Article
Genetic and pathogenetic insights into inflammatory bowel disease.
Current gastroenterology reports - 1 Dec 2003
Pallone Francesco, Blanco Giovanna Del Vecchio, Vavassori Piero, Monteleone Ivan, Fina Daniele, Monteleone Giovanni
Abstract excerpt
Crohn's disease (CD) and ulcerative colitis (UC) are chronic inflammatory disorders of the gastrointestinal tract that share clinical and pathologic characteristics. The most credible hypothesis is that CD and UC result from an inappropriate and exaggerated mucosal immune response to normal constituents of the mucosal microflora that is in part genetically determined. However, there is reason to believe that the...
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