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The Genetic Basis of Inflammatory Bowel Disease

1 Jan 2009

Abstract excerpt

Twin studies and large-scale population studies have confirmed an increased sibling risk for both Crohn's disease (CD) and ulcerative colitis (UC). Unlike single gene disorders, CD and UC are thought to result from a complex interplay of multiple genes and environmental factors. The confirmation of CARD15/NOD2 as a CD susceptibility gene in the late 1990s caused much excitement in the field of complex diseases in...

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PMID: 19897957
DOI: 10.1159/000234909

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