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Article

Deletion of the heparin-binding epidermal growth factor-like growth factor gene increases susceptibility to necrotizing enterocolitis.

Journal of pediatric surgery - 1 Apr 2010

Radulescu Andrei, Yu Xiaoyi, Orvets Nathan D, Chen Yan, Zhang Hong-Yi, Besner Gail E

Abstract excerpt

BACKGROUND: Necrotizing enterocolitis (NEC) is the leading surgical cause of death in premature infants. We have accumulated evidence supporting a role for heparin-binding epidermal growth factor (EGF)-like growth factor (HB-EGF) in protection of the intestines from NEC. The aim of the current study was to evaluate the effect of loss-of-function of endogenous HB-EGF on susceptibility to NEC. METHODS: Neonatal...

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Source

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Identifiers

PMID: 20385279
DOI: 10.1016/j.jpedsurg.2009.06.035
PMCID: PMC2855155

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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