Article
The chicken polydactyly (Po) locus causes allelic imbalance and ectopic expression of Shh during limb development.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 May 2011
Dunn Ian C, Paton I Robert, Clelland Allyson K, Sebastian Sujith, Johnson Edward J, McTeir Lynn, Windsor Dawn, Sherman Adrian, Sang Helen, Burt Dave W, Tickle Cheryll, Davey Megan G
Abstract excerpt
Point mutations in the intronic ZRS region of Lmbr1, a limb specific cis-regulatory element of Sonic hedgehog (Shh), are associated with polydactyly in humans, cats, and mice. We and others have recently mapped the dominant preaxial polydactyly (Po) locus in Silkie chickens to a single nucleotide polymorphism (SNP) in the ZRS region. Using polymorphisms in the chicken Shh sequence, we confirm that the ZRS region...
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